Books

1.    Kost, J. (Author/Editor) "Pulsed and Self Regulated Drug Delivery", CRC Press, 1990.

2.    Cohn, D. and Kost, J. (Author/Editor) "Biomedical Polymers, Molecular Design to Clinical Applications" Elsevier Applied Science, 1993.

3.    Domb, A., Kost, J. and Wiseman, D. "Handbook of Bioerodible Polymers" Harwood Academic Publishers GMBH, 1997.

4.    Shroeder, A., Kost, J., Barenholz, Y. “Controlled Release of Drugs from Liposomes” VDM Verlag Press, 2010.


5.    Kost, J. and Wojcicki, J.M. (Eds) Lecture Notes of the ICB Seminar, 1st Polish-Israeli Seminar, Biomedical Engineering Approaches in Chronic Diseases, MCB, IBIB, PAN 2012.


Chapters in Books

1.    Horbett, T., Ratner, B., Kost, J., Manindar, S. "A Bioresponsive Membrane for Insulin Delivery", in: Recent Advances in Drug Delivery Systems, Anderson, J.M. and Kim, S.W. (Eds.), Plenum Press, 1984, pp. 209-220.

2.    Horbett, T., Kost, J., Ratner, B. "Swelling Behavior of Glucose Sensitive Membranes", in: Polymers as Biomaterials, S. Shalaby, A.S. Hofmann, B.D. Ratner and T.A. Horbett (Eds.), Plenum Press, 1985, pp. 193-207.

3.    Edelman, E., Linhardt, R., Bobeck, H., Kost, J., Rosen,H., Langer,R. "Polymer Based Drug Delivery: Magnetically Modulated and Bioerodible Systems", in: Polymers as Biomaterials, S. Shalaby, A.S. Hoffman, B.D. Ratner and T.A. Horbett (Eds.), Plenum Press, 1985, pp. 279-292.

4.    Kost, J., Langer, R. "Equilibrium Swollen Hydrogels in Controlled Release Applications", in: Hydrogels in Biomedical and Pharmaceutical Applications, Peppas, N. (Ed.), CRC Press, 1987, Chapter 5, pp. 95-108.

5.    Kost, J., Leong, K., Langer, R. "Ultrasonic Modulated Drug Delivery Systems in Polymers in Medicine", in:  Biomedical and Pharmaceutical Applications, II, Chiellini, E. (Ed.), Plenum Press, 1986, pp. 387 - 396.

6.    Kost, J. "Externally Modulated Drug Delivery Devices in Drug Delivery Devices", in: Pharmaceutical and Biological Applications, Tyle, P. (Ed.), Marcel Dekker, 1988, pp.369-   384.

7.    Kost, J. "Magnetically Controlled Drug Delivery Systems", in: Current Perspectives on Implantable Devices, William, D.F. (Ed.), JAI Press, 1989, 1, pp.203-217.

8.    Kost, J., Levy, D., Langer, R. "Ultrasound as a Transdermal Enhancer", in: Percutaneous Absorption, Maibach, H. (Ed.), Marcel Dekker, 1989, pp 595-601.

9.    Kost, J., Langer, R. "Magnetically and Ultrasonically Modulated Drug Delivery Systems", in: Pulsed and Self Regulated Drug Delivery, Kost, J. (Ed.), CRC Press, 1990, pp 3-16.

10.  Langer, R., Kost, J. "Real Time Response Polymeric Delivery Systems", in: Temporal Control of Drug Delivery, Hrushesky, W, Langer, R, Theeuwes, F. (Eds.), Annals of the N.Y. Academy Science, 1991, pp 330-334.

11.  Kost, J., Langer, R. "Ultrasound Mediated Transdermal Drug Delivery", in: Topical Drug Bioavailability, Bioequivalence and Penetration, Shah, V., Maibach, H. (Eds.), Plenum Press, 1993, pp 91 -104.

12.  Kost, J. "Biomaterials in Drug Delivery Systems", in: Handbook of Biomaterials and Applications, Altobelli, D., Schwartz E., Yaszemski, M., Gresser, J., Trantolo, D., and Wise, D. (Eds.), Marcel Dekker, 1995, pp 2227-2251.

13.  Machluf, M., Kost, J. "Ultrasonically Enhanced Transdermal Drug Delivery, Experimental Approaches to Elucidate the Mechanism", in: Polymer Biomaterials in Solution, as Interfaces and as Solids, Cooper, S.L., Bamford, S.H., and Tseuruta, T. (Eds.), VSP, 1996, pp 821-830.

14.  Kost, J. "Glucose Responsive Hydrogels for Medical Applications", in: Polymeric Materials Encyclopedia, Salamone, J. (Ed.), CRC Press, 1996, pp 2825-2829.

15.  Kost, J. "Polymeric Controlled Drug Delivery Systems", in: Polymeric Materials Encyclopedia, Salamone, J. (Ed.) CRC Press, 1997, pp 1509-1519.

16.  Kost, J. "Ultrasound Triggered Delivery of Peptides and Proteins from Microspheres", in: Microparticulate Systems for the Delivery of Proteins and Vaccines, Cohen, S. and Bernstein, H. (Eds.), Marcel Dekker, 1996, pp 463- 476.

17.  Kost, J., Goldbart, R. "Natural and Modified Polysaccharides", in: Handbook of Bioerodible Polymers, Domb, A., Kost, J. and Wiseman, D. (Eds.), Harwood Academic Publishers GMBH, 1997, pp 275-289.

18.  Kost, J. "Phonophoresis" in: Electrically Controlled Drug Delivery, Berner, B. and Dinh, S. (Eds.), CRC Press, 1998, pp 215-228.

19.  Kost, J., Mitragotri, S., Langer, R. "Phonophoresis", in: Percutaneous Absorption-3rd Editon, Maibach, H. and Bronaugh, R. (Eds.), Marcel Dekker, 1999, pp 615-631.

20.  Kost, J. "Intelligent Drug Delivery Systems", in: The Encyclopedia of Controlled Drug Delivery, Mathiowitz, E. (Ed.), John Wiley & Sons, 2000, pp 445-459.

21.  Liu. L-S., Kost, J. "Nano/Microspheres from Natural Polymers", in: Sustained Release Injectable Products, Senior, J. and Radomsky, M. (Eds.), Interpharm Press, 2000, pp 203-240.

22.  Geresh, S., Peisahov, J., Voorspoels, J., Remon, J-P., and Kost, J. "Preparation and Characterization of Buccal Bioadhesives from Starches Grafted with Acrylic Monomers", in: New Biomedical Materials, Haris, P.I. and Chapman, D. (Eds.), IOS Press, 1998, pp 192-196.

23.  Mitragotri, S., Langer, R., Kost, J. "Ultrasound for Modulation of Skin Transport Properties", in: Biomaterials and Bioengineering Handbook, Wise, D., Trantolo, D., Altobeli, D., Yazemski, M., Wnek, G., and Gresser, J. (Eds.), Marcel Dekker, 2000, pp 843-854.

24.  Mitragotri, S., Kost, J., Langer, R. "Enhancement of Transdermal Transport Using Ultrasound Combination with Other Enhancers", in: Handbook of Pharmaceutical Controlled Release Technology, Wise, D. (Ed.), Marcel Dekker, 2000, pp 607-616.

25.  Kost, J., Lapidot, S. "Smart Polymers - for Controlled Drug Delivery", in: Handbook of Pharmaceutical Controlled Release Technology, Wise, D. (Ed.), Marcel Dekker, 2000, pp 65-87.

26.  Kost, J., Lapidot, S. "Drug Delivery Systems", in: Encyclopedia of Smart Materials, Harvey, J. (Ed.), John Wiley & Sons, 2002 Volume 1, pp 319-330.

27.  Lapidot, S., Kost, J. "Hydrogels", in: Encyclopedia of Materials: Science and Technology, Buschow, J., Cahn, R., Flemings, M., Ilschner, B., Kramer, E., and Mahajan, S. (Eds.), Elsevier Science, 2001, pp 3878-3882.

28.  Kost, J. "Ultrasound and Transdermal Transport for Drug Delivery and Diagnostics" in: Business Briefing; PharmaTech third edition, 2001, pp 196-202.

29.  Kost, J., Mitragotri, S., Langer, R. "Phonophoresis", in: Topical Absorption of Dermatological Products, Bronaugh, R. and Maibach, H. (Eds.), Marcel Dekker, 2002, pp 335-351.

30.  Mitragotri, S., Kost, J. "Ultrasound Mediated Transdermal Drug Delivery", in: Modified-Release Drug Delivery Technology, Rathbone, M.R., Roberts, M.S., and Hadgraft, J. (Eds.), Marcel Dekker, 2003, pp 561-570.

31.  Kost, J., Lapidot, S. "Drug Delivery Systems", in: Kirk-Othmer Encyclopedia of Chemical Technology, online 5th edition John Wiley & Sons, 2004, pp 319-330.

32.  Liu, L, Kost, J., Fishman, M. and Hicks, K. “A Review: Controlled Release Systems for Agricultural and Food Applications”  in New Delivery Systems for the Controlled Drug Release from Naturally Occurring Materials, by N. Parris, L. S. Liu, C. Song and V. P. Shastri (Eds.): ACS Symposiuim Series 992, 2008, pp.265-281.

33.  Kost, J., Wolloch, L. "Ultrasound in Percutaneous Absorption", in: Enhancement in Drug Delivery, Touitou, E., and Barry, W. (Eds.), CRC Press, 2006, pp 317-330.

34.  Kost, J. "Drug Delivery Systems: Smart Polymers", in: Smart Materials, Schwartz, M. (Ed.), Taylor & Francis/CRC Press, 2009, pp 31/10-15.

35.  Kost, J. "Blotting from PhastGel to Membranes by Ultrasound", in: Methods in Molecular Biology, Protein Blotting and Detection, vol. 536, Kurien, B. and Scofield, H. (Eds.), Humana Press, 2009, pp 173-179.

36.  Kost, J. “Sonophoresis” in Therapeutic Ultrasound, Frenkel, V. (Ed), Nova Science 2011. p. 165-183.


37.  Kost, J., Azagury, A., "Blotting from PhastGel to Membranes by Ultrasound" in: Methods in Molecular Biology, vol. 1312, Western Blotting: Methods and Protocols, Kurien, B. and Scofield, R,H. (Eds.) Springer Protocols, Human Press, 2015, pp 237-246

 

 

Papers

1.    Kost, J. Reuse of Plastics Wastes. Publication of the Israel Plastics Society, 4, 17-20, 1974.

2.    Ram, A., Narkis, M. and Kost, J. Reuse of Plastics from Solid Wastes, Polymer Engineering and Science, 17, 274-278, 1977.

3.    Siegman, A., Narkis, M., Kost, J. and Di Benedetto, A. T. Mechanism of Low Profile Behavior in Unsaturated Polyester System. Journal Polymeric Materials, 6, 217-231, 1978.

4.    Gutman, D., Minkov, B., Kost, J. and Ben Arieh, H. The Quantitative Measurement of Occlusion by Photoplasticity. Actualities Odonto- Stomatologiques, 138, 273-280, 1982.

5.    Kost, J., Narkis, M. and Foux, A. Effects of Axial Stretching on the Resistivity of Carbon Black Filled Silicone Rubber. Polymer Engineering and Science, 23, 567-571, 1983.

6.    Horbett, T., Kost, J. and Ratner, B. Swelling Behavior of Glucose Sensitive Membranes. ACS Polymer Reprints, 24(1), 34-35, 1983.

7.    Kost, J., Narkis, M. and Foux, A. Resistivity Behavior of Carbon Black Filled Silicone Rubber in Cycling Loading Experiments. Journal of Applied Polymer Science, 29, 3937-3946, 1984.

8.    Kost, J. and Langer, R. Controlled Release of Bioactive Agents. Trends in Biotechnology, 2, 47-51, 1984.

9.    Edelman, E., Brown, L., Kost, J., Taylor, J. and Langer, R. Modulated Release from Polymeric Drug Delivery Systems Using Oscillating Magnetic Fields: In Vitro and In Vivo Characteristics. Trans. Am. Soc. Artif. Intern. Organs, 30, 445-449, 1984.

10.  Langer, R., Siegel, R., Brown, L., Leong, K., Kost, J. and Edelman, E. Controlled Release Systems: Some Recent Advances. Proc. of the ACS Division of Polymeric Materials: Science & Engineering, 51, 115-118, 1984.

11.  Kost, J. and Langer, R., Liberation Controlee de Substances Bioactives. Biofutur, Juillet, 27-31, 1984.

12.  Edelman, E., Kost, J., Bobeck, H. and Langer, R. Regulation of Drug Release from Polymer Matrices by Oscillating Magnetic Fields. Journal of Biomedical Materials Research, 19, 67-83, 1985.

13.  Gutman, D., Minkov, B., Kost, J., Carmeli, Y. and Ben-Aryeh, H. Occlusal Adjustment by Photoocclusion. The Journal of Prosthetic Dentistry, 53, 238-243, 1985.

14.  Kost, J., Horbett, T., Ratner, B. and Singh, M. Glucose Sensitive Membranes Containing Glucose Oxidase: Activity, Swelling and Permeability Studies. Journal of Biomedical Materials Research, 19, 1117-1133, 1985.

15.  Langer, R., Brown, L., Edelman, E., Kost, J. and Leong, K. Controlled Release and Magnetically Modulated Systems for Macromolecular Drugs. Annals of the New York Academy of Sciences, New York, 446, 1-13, 1985.

16.  Kost, J. and Langer, R. Magnetically Modulated Drug Delivery Systems, Pharmacy International, 7, 60-64, 1986.

17.  Kost, J., Noecker, R., Kunica, E. and Langer, R. Magnetically Controlled Release Systems: Effect of Polymer Composition. Journal of Biomedical Materials Research, 19, 935-940, 1985.

18.  Langer, R., Siegel, R., Brown, L., Leong, K., Kost, J. and Edelman E. Controlled Release: Three Mechanisms. Chemtech. Feb., 108-110, 1986.

19.  Leong, K., Kost, J., Mathiowitz, E. and Langer, R. Polyanhydrides for Controlled Release of Bioactive Agents. Biomaterials, 7, 364-371, 1986.

20.  Kost, J. and Langer, R. Magnetically Modulated Drug Delivery Systems, Advances in Drug Delivery, 11, 19-24, 1986 (Japanese).

21.  Kost, J., Wolfrum, J. and Langer, R. Magnetically Enhanced Insulin Release in Diabetic Rats. Journal of Biomedical Materials Research, 21, 1367-1373, 1987.

22.  Kost, J. Polymers in Medicine. Polymers and Plastics in Israel, 1, 14-17, 1988.

23.  Kost, J. Implantable Therapeutic Systems. Annual Review of Chronopharmacology, 5, 415-418, 1988.

24.  Kost, J., Leong, K. and Langer, R. Ultrasonically Controlled Polymeric Drug Delivery. Die Makromolekulare Chemie, Macromolecular Symposia, 19, 275-285, 1988.

25.  Kost, J. Polymeric Controlled Drug Delivery Systems. Proc. 4th Israel Materials Engineering Conference, Israel Journal of Technology, 24, 653-660, 1988.

26.  Siegel, R., Kost, J. and Langer, R. Mechanistic Studies of Macromolecular Drug Release from Macroporous Polymers. I. Experiments and Preliminary Theory Concerning Completeness of Drug Release. Journal of Controlled Release, 8, 223-236, 1989.

27.  Levy, D., Kost, J., Meshulam, Y. and Langer, R. Effect of Ultrasound on Transdermal Drug Delivery to Rats and Guinea Pigs. J. Clin. Invest., 83, 2074-2078, 1989.

28.  Kost, J., Leong, K. and Langer R. Ultrasound-Enhanced Polymer Degradation and Release of Incorporated Substances. Proceedings of the National Academy of Sciences, U.S.A., 86, 7663-7666, 1989.

29.  Kost, J. and Langer, R. Responsive Polymeric Delivery Systems, Advanced Drug Delivery Reviews, 6, 19-50, 1991.

30.  Kost, J. and Shefer, S. Chemically Modified Polysaccharides for Enzymatically Controlled Oral Drug Delivery, Biomaterials, 11, 695-698, 1990.

31.  Kost, J. and Shefer, S. Natural Polysaccharides for Enzymatically Controlled Drug Delivery. Polymer Preprints, 31, 1, 235, 1990.

32.  Kost, J. and Shefer, S. Chemically-Modified Starches for Targeted Drug Delivery. ACS Polymeric Materials Science and Engineering, 63, 47-50, 1990.

33.  D'Emanuele, A., Kost, J., Hill, J. and Langer, R. Effects of Ultrasound on the Erosion of Polymer Matrices. J. Pharm. Pharmacol., 43, 78, 1991.

34.  D'Emanuele, A., Kost, J., Hill, J. and Langer, R. An Investigation of the Effect of Ultrasound on Degradable Polyanhydride Matrices, Macromolecules, 25, 511-515, 1992.

35.  Liu, L-S., Kost, J., D'Emanuele, A. and Langer, R. Experimental Approaches to Elucidate the Mechanism of Ultrasound-Enhanced Polymer Erosion and Release of Incorporated Substances. Macromolecules, 25, 123-128, 1992.

36.  Kost, J. and Langer, R. Responsive Polymer Systems for Controlled Delivery of Therapeutics, Trends in Biotechnology, 10, 127-131, 1992.

37.  Shefer, A., Shefer, S., Kost, J. and Langer, R. Structural Characterization of Starch Networks in the Solid State by Cross-Polarization Magic-Angle-Spinning 13C-N.M.R. Spectroscopy and Wide Angle X-ray Diffraction. Macromolecules, 25, 6756-6760, 1992.

38.  Goldraich, M. and Kost, J. Glucose-Sensitive Polymeric Matrices for Controlled Drug Delivery. Clinical Materials, 13, 135-142, 1993.

39.  Kost, J. Ultrasound for Controlled Delivery of Therapeutics. Clinical Materials, 13, 155-161, 1993.

40.  Kost, J. Ultrasound Induced Delivery of Peptides. Journal of Controlled Release, 24, 247-255, 1993.

41.  Machluf, M. and Kost, J. Ultrasonically Enhanced Transdermal Drug Delivery: Experimental Approaches to Elucidate the Mechanism. Journal of Biomaterials Science, 5, 147-156, 1994.

42.  Kost, J., Foux, A. and Narkis, M. Quantitative Model Relating Electrical Resistance Strain and Time for Carbon Black Loaded Silicone Rubber. Polymer Engineering and Science, 34, 1628-1634, 1994.

43.  Kost, J., Liu, L-S., Ferreira, J. and Langer, R. Enhanced Protein Blotting from PhastGel Media to Membrane by Irradiation of Low Intensity Ultrasound. Analytical Biochemistry, 216, 27-32, 1994.

44.  Kost, J., Liu, L-S., Gabelnick, H. and Langer, R. Ultrasound as a Potential Trigger to Terminate the Activity of Contraceptive Delivery Implants. Journal of Controlled Release, 30, 77-81, 1994.

45.  Kost, J. Hydrogels for Controlled Delivery of Bioactive Agents. Polymer News, 20, 73-80, 1995.

46.  Friling, R., Yassur, Y., Levy, R., Kost, J. and Lamprecht, S. A Role of Transforming Growth Factor 1 in the Control of Corneal Neovascularization.  In vivo, 10, 59-64, 1996.

47.  Eliaz, R., Wallach, D. and Kost, J. Long-Term Protection Against Tumor Necrosis Factor (TNF) Effects by Controlled Delivery of Soluble p55 TNF Receptor. Cytokine, 8, 482-487, 1996.

48.  Kost. J., Pliquett, U., Mitragotri, S., Yamomoto, A., Langer, R. and Weaver, J. Synergistic Effect of Electric Field and Ultrasound on Transdermal Transport. Pharmaceutical Research, 13, 631-636, 1996.

49.  Band, M., Gutman, M., Faerman, V., Korengold, E., Kost, J., Plath, P.J. and Guntar, V. Influence of Specially Modulated Ultrasound on the Water Desalination Process with Ion-Exchange Hollow Fibers. Desalination, 109, 303-307, 1997.

50.  Machluf, M., Regev, O., Peled, Y., Kost, J. and Cohen, S. Characterization of Microencapsulated Liposome Systems for the Controlled Delivery of Liposomal Antigens. Journal of Controlled Release, 43, 35-41, 1997.

51.  Schwartz, M., Guterman, H. and Kost, J. Electrical Properties of Glucose-Sensitive Hydrogels: Swelling and Conductivity Relations, Journal of Biomedical Materials Research, 41, 65-70, 1998.

52.  Eliaz, R., Grossman, N., Katz, S., Zur-Mashiach, R., Grunwald, M., Reuveni, H., Rosenberg, L. and Kost, J. In Vitro Analysis of Bromine Chemical Burns Using Full-Thickness Human Skin. Burn Care & Rehabilitation, 19, 18-24, 1998.

53.  Lavon, I. and Kost, J. Mass Transport Enhancement by Ultrasound in Non-Degradable Polymeric Controlled Release Systems. Journal of Controlled Release, 54, 1-7, 1998.

54.  Mikhailowski, R., Shpitz, B., Polak-Charcon, S., Kost, J., Segal, C., Fich, A. and Lamprecht, S. Controlled Release of TGF-1 Impedes Colon Carcinogenesis In- Vivo. International Journal of Cancer, 78, 618-623, 1998.

55.  Goldbart, R. and Kost, J. Calcium Responsive Bioerodible Drug Delivery System. Pharmaceutical Research, 16, 1485-1488, 1999.

56.  Eliaz, R. and Kost, J. Characterization of a Polymeric PLGA-Injectable Implant Delivery System for the Controlled Release of Proteins. Journal of Biomedical Materials Research, 50, 388-396, 2000.

57.  Mitragotri, S., Farrell, J., Tang, H., Terahara, T., Kost, J. and Langer, R. Determination of Threshold Energy for Ultrasound-Induced Transdermal Drug Delivery. Journal of Controlled Release, 63, 41-52, 2000.

58.  Kost, J., Mitragotri, S., Gabbay, R., Pishko, M. and Langer, R. Transdermal Monitoring of Glucose and Other Analytes Using Ultrasound. Nature Medicine, 6, 347-350, 2000.

59.  Mitragotri, S., Ray, D., Farrel, J., Tang, H., Yu, B., Kost, J., Blankschtein, D. and Langer, R. Synergistic Effect of Ultrasound and Sodium Lauryl Sulfate on Transdermal Transport. Journal of Pharmaceutical Sciences, 89, 892-900, 2000.

60.  Mitragotri, S., Coleman, M., Kost, J. and Langer, R. Transdermal Extraction of Analytes Using Ultrasound. Pharmaceutical Research, 17, 466-470, 2000.

61.  Mitragotri, S., Kost, J. and Langer, R. Non-Invasive Drug Delivery and Diagnostics Using Low Frequency Sonophoresis. Recent Advances and Research Updates in Medicine, 1, 41-48, 2000.

62.  Traitel, T., Cohen, Y. and Kost, J. Characterization of Glucose-Sensitive Insulin Release Systems in Simulated In-Vivo Conditions. Biomaterials, 21, 1679-1687, 2000.

63.  Eliaz, R., Wallach, D. and Kost, J. Delivery of Soluble Tumor Necrosis Factor Receptors from In Situ Forming PLGA implants: in-vivo. Pharmaceutical Research, 17, 1546-1550, 2000.

64.  Mitragotri, S., Coleman, M., Kost, J. and Langer, R. An Analysis of Ultrasonically Extracted Interstitial Fluid as a Predictor of Blood Glucose Levels.  J. Appl. Physiol. 89, 961-966, 2000.

65.  Le, L., Kost, J. and Mitragotri, S. Combined Effect of Low-Frequency Ultrasound and Iontophoresis: Applications for Transdermal Heparin Delivery. Pharmaceutical Research, 17, 1151-1154, 2000.

66.  Mitragotri, S. and Kost, J. Low-Frequency Sonophoresis: A Noninvasive Method of Drug Delivery and Diagnostics. Biotechnol. Prog., 16, 488-492, 2000.

67.  Kost, J., and Langer, R., Responsive Polymeric Delivery Systems, Advanced Drug Delivery Reviews, 46, 125-148, 2001 (special issue, see ref 29. Most Highly Cited Articles 1991-1998).

68.  Mitragotri, S. and Kost, J. Transdermal Delivery of Heparin and Low-Molecular Weight Heparin Using Low-Frequency Ultrasound. Pharmaceutical Research, 18, 1151-1156, 2001.

69.  Terehara, T., Mitragotri, S., Kost, J. and Langer, R. Dependence of Low-Frequency Sonophoresis on Ultrasound Parameters; distance of the horn and intensity. International Journal of Pharmaceutics, 235, 35-42, 2002.

70.  Kost, J. Ultrassound-Assisted Insulin Delivery and Noninvasive Glucose Sensing. Diabetes Technology & Therapeutics, 4, 489-497, 2002.

71.  Goldbart, R., Traitel, T., Lapidot, S. and Kost J. Enzymatically Controlled Responsive Drug Delivery Systems. Polymers For Advanced Technologies, 13, 1006-1018, 2002.

72.  Geresh, S., Gilboa, Y., Peisahov_Korol, J., Gdalevsky, G. and Kost, J. Bioadhesive Grafted Starch Co-Polymers as Platforms for Peroral Controlled Drug Delivery: Preparation and Characterization. J. Appl. Polym. Sci., 86, 1157-1162, 2002. (C 26; IF 1.64; Q1)

73.  Liu, L, Fishman, M., Kost, J. and Hicks, K. Pectin Based Systems for Colon-Specific Drug Delivery Via Oral Route, Review. Biomaterials, 24, 3333-3343, 2003.

74.  Traitel, T., Kost, J. and Lapidot, S. Modeling Ionic Hydrogels Swelling. Biotechnology & Bioengineering, 84, 20-28, 2003.

75.  Geresh, S., Gdalevsky, G., Gilboa, Y., Voorspoels, J., Remon, J.P. and Kost, J. Bioadhesive Grafted Starch Co-Polymers as Platforms for Peroral Drug Delivery: A Study of Theophyline release. Journal of Controlled Release, 94, 391-399, 2004.

76.  Katz, N., Shapiro, D., Hermann, T., Kellogg, S., Warner, N., Kost, J. and Custer, L. Rapid Onset of Cutaneous Anesthesia with EMLA Cream After Pretreatment with a New Ultrasound-Emitting Device, Anesthesia & Analgesia, 98, 371-376, 2004.

77.  Mitragotri, S. and Kost, J. Low-Frequency Sonophoresis: A Review. Advanced Drug Delivery Reviews, 56, 589-601, 2004.

78.  Lavon, I. and Kost, J. Ultrasound and Transdermal Drug Delivery. Drug Discovery Today, 9, 670-676, 2004.

79.  Traitel, T. and Kost, J. pH-responsive hydrogels: swelling model. Adv. Exp. Med. Biol., 553, 29-43, 2004.

80.  Eliaz, R. and Kost, J. Applications of Injectable Polymeric Implants for Proteins and DNA Delivery. Israel Journal of Chemistry, Special Issue on Degradable Biopolymers, 45, 437-444, 2005.

81.  Lavon, I., Grossman, N. and Kost, J. The Nature of Ultrasound-SLS Synergism During Enhanced Transdermal Transport. Journal of Controlled Release, 107, 484-494, 2005.

82.  Aschkenasy, C. and Kost, J. On-Demand Release by Ultrasound From Osmotically Swollen Hydrophobic Matrices. Journal of Controlled Release, 110, 58-66, 2005.

83.  Acharya, S., Patla, I., Kost, J., Efrima, S. and Golan, Y. Switchable Assembly of Ultra Narrow CdS Nanowires and Nanorods. J. Am. Chem. Soc., 128, 9294 - 9295, 2006.

84.  Shroeder, A., Kost, J. and Barenholz, Y. Liposomal Drug Targeting. Galileo, 90, 36-40, 2006.

85.  Lavon, I., Grossman, N., Kost, J., Kimmel, E. and Enden, G. Bubble Growth within the Skin by Rectified Diffusion Might Play a Significant Role in Sonophoresis.  Journal of Controlled Release, 117, 246-255, 2007.

86.  Shroeder, A., Avnir, Y., Weisman, S., Tzemach, D., Najajreh, Y., Gabizon, A., Talmon, Y., Kost, J. and Barenholz, Y. Controlling Liposomal Drug Release by Low-Frequency Ultrasound: Mechanism and Feasibility. Langmuir, 23, 4019-4025, 2007.

87.  Traitel, T., Goldbart, R., and Kost, J. Smart Polymers for Responsive Drug Delivery; Review, Journal of Biomaterials Science, Polymer Edition, 19, 755-767, 2008.

88.  Katav, T.,  Liu LS, Traitel, T., Goldbart, R., Wolfson, M. And Kost, J.  Modified Pectin-based Carrier for Gene Delivery: Cellular Barriers in Gene Delivery Course.  Journal of Controlled Release, 130, 183-191, 2008.

89.  Gurfinkel, R., Lavon, I., Cagnano, E., Volgin, V., Shaltiel, L., Grossman, N., Kost, J., Singer, A., Rosenberg L. “Combined Ultrasonic and Enzymatic Debridement of Necrotic Eschars in an Animal Model” J of Burn Care & Reserach, 30, 505-513, 2009.

90.  Shroeder, A., Honen, R., Turieman, K., Gabizon, A., Kost, J., and Barenholz, Y. “Ultrasound Triggered Release of Cisplatin from Liposomes in Murine Tumors” Journal of Controlled Release, 137, 63-68, 2009.

91.  Shroeder, A., Kost, J., and Barenholz, Y. “Ultrasound, Liposomes and Drug Delivery: Principles for Using Ultrasound to Control the Release of Drugs from Liposomes” Chemistry and Physics of Lipids, 162, 1–16, 2009.

92.  Park, H., Yip, M., Kost, J., Kobler, J., Langer, R., and Zeitels, A. “Effects of Indirect Low-Intensity Ultrasonic Stimulation on Mouse Muscle Cells and Human Adipose Tissues“ Journal of Tissue Engineering Volume 2010, Article ID 973530, 9 pages, doi:10.4061/2010/973530, 2010.

93.  Wolloch, L., and Kost, J. The Importance of Microjets vs Shock Waves Formation in Sonophoresis,  Journal of Controlled Release, 148, 204-211, 2010.

94.  Lang, S., Tofail, S., Gandhi, A., Gregor, M., Wolf-Brandstetter, C., Kost, J., Bauer, S, and Krause, M. Pyroelectric, piezoelectric and photoeffects in hydroxyapatite thin films on silicon” Appl. Phys Lett, 98, 123703 , doi:10.1063/1.3571294, 2011.

95.  Liu, L., Kost, J., Yan, F., and Spiro, R. "Hydrogels from Biopolymers Hybrid for Biomedical, Food, and Functional Food Applications" Polymers,  4, 997-1011; doi:10.3390/polym4020997, 2012.

96.  Kost, J., and Langer, R., Responsive Polymeric Delivery Systems, Advanced Drug Delivery Reviews, 64, 327-341, 2012 (special issue, see ref 29. Most Cited Papers in the History of Advanced Drug Delivery Reviews: A Tribute to the 25th Anniversary of the Journal, Theme Editor N.A. Peppas).

97.  Hernandez, LV., Triadafilopoulos, G., Kost, J., Ganz, RA., Ton, M., Klyve, D., Lewis, GK.. Salvaging Poorly Prepared Colonoscopies Using Endoluminal Ultrasound: a Pilot Study. Gastrointestinal Endoscopy, 77 (5), supplement AB429-AB430, 2013.

98.  Goldian, I., Traitel, T., Goldbart, R., and Kost, J. Low Frequency Ultrasound Effects on Intracellular Barriers in Non-Viral Gene Delivery Process, Israel Journal of Chemistry, 53, 829-838, 2013.

99.  Azaguri, A., Amar-Lewis, E., Mann, E., Goldbart, R., Traitel, T., Jelinek, R., Hallak, M., and Kost, J. A novel approach for noninvasive sensing and delivery through the amniotic sac.  Journal of Controlled Release, 183,105-113, 2014.

100.       Hernandez, L., Triadafilopoulos, G., Kost, J., Ganz, R., Fleshman, S., Klyve, D., Ton, M., and Lewis, G.. A Pilot Study of Endoluminal Ultrasound for Stool Liquefaction, Gastrointestinal Endoscopy 79, 508-513, 2014.

101.       Azaguri, A.,Khoury, L., Enden, G., and Kost, J. Ultrasound induced transdermal drug delivery,  Advanced Drug Delivery Reviews,  72, 127-143, 2014 http://dx.doi.org/10.1016/j.addr.2014.01.007.

102.       Wolloch, L., Azaguri, A., Goldbart, R., Traitel, T., Groisman, G., Hallak, M., and Kost, J. Fetal Membrane Transport Enhancement Using Ultrasound, Pharmaceutical Research, 32, 403-413, 2015.  DOI 10.1007/s11095-014-1470-8.

103.       Galina Shapiro, G., Kallai, I., Sheyn,D., Tawackoli, W., Cohn-Yakubovich, D., Koh, Y.D.,  Bae, H., Tamar Trietel, T., Goldbart,R.,  Kost, J., Gazit, Z.,Gazit, D. and Pelled, G. Ultrasound – mediated Transgene Expression In Endogenous Stem Cells Recruited to Bone Injury Sites. Polymers for Advanced Technologies, 25, 525-531, 2014, DOI: 10.1002/pat.3297.

104.       Amar-Lewis, E., Azaguri, A., Goldbart, R., Traitel, T., Prestwood, J., Landesman-Milo, D., Peer, D and Kost, J. Quaternized Starch-Based Carrier for siRNA Delivery: from Cellular Uptake to Gene Silencing. Journal of Controlled Release, 185, 109-120, 2014, http://dx.doi.org/10.1016/j/jconrel.2014.04.031.

105.       Sieradzki, R., Traitel, T., Goldbart R.,, Geresh, S., and Kost, J.  Tailoring quaternized starch as a non-viral carrier for gene delivery applications, Polymers for Advanced Technologies, 25, 552-561, 2014, DOI: 10.1002/pat.3277).

106.       Laster, B., Isaacson, C. Perets, E., Msamra, M., Priel, E., Kalef-Ezra, J., Kost, J. Keep those Telomeres Short!  An Innovative Intratumoral Long-Term Drug Delivery System. Journal of Cancer Research and  Clinical Oncology,  DOI. 10.1007/s00432-014-1747-7 (published online  30 July 2014).

107.       Azagury, A., Khoury, L., Adato,Y., Wolloch, l., Ariel, I., Hallak, M., and Kost, J. The Synergistic Effect of Ultrasound and Chemical Penetration Enhancers on Chorioamnion Mas Transfer, Journal of Controlled Release, 200, 35-41, 2015

108.       Khoury, L., Goldbart, R., Traitel, T., Enden, G and Kost, J. Harvesting Low Molecular Weight Biomarkers Using Gold Nano Particle, ACS Nano, 9,6, 5750-5759, 2015; DOI: 10.1021/nn507467y

109.       Kachko, I., Traitel, T., Goldbart, R., Silbert, L., Katz, M., Bashan, N., Jelinek, R., Rudich, A., and Kost, J. Polymeric Carrier-Mediated Intracellular Delivery of Phosphatidylinositol-3,4,5 – Triphosphate to Overcome Insulin Resistance J. Drug Targeting, 23 (7-8), 698-709, 2015.

110.       Azagury, A., Amar-Lewis, E., Yudilevitch, Y., Isaacson, C., Laster, B., and Kost, J. Ultrasound Effect on Cancerous Vs. Non-cancerous Cells, Ultrasound in Medicine and Biology, 42,7, 1560-1567, 2016.

111.       Wang, Q., Dong, B., Firrman, J., Wu, W., Roberts, S., Moore, A., Liu, L S., Chin, M., Diao, Y., Kost, J. and Xiao, W. Evaluation of the biological differences of canine and human factor VIII in gene delivery: implications in human hemophilia treatment, Gene Therapy 23, 597-605, 2016

112.       Chintakunta, R.,  Buaron, N.,  Kahn, N., Moriah, A., Lifshiz, R., Goldbart, R., Traitel, T.,  Tyler, B., Brem, H., and Kost, J.Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging application, Carbohydrate Polymers, 150, 308-318, 2016.

113.       Kost, J. Intelligent Systems for the Delivery of Drugs and Genes, Igeret 38,  42-51, 2016, (in Hebrew, Publication of The Israel Academy of Sciences and Humanities)

114.       Azagury, A., Amar-Lewis, E., Appel, R., Hallak, M., and Kost, J. Amplified CPEs Enhancement of Chorioamnion Membrane Mass Transport by Encapsulation in Nano-sized PLGA Particles, European Journal of Pharmaceutics and Biopharmaceutics, 117, 292-299, 2017

115.       Ghiuta, I., Kost, J., Wenkert, R., Vyrides, I., Anayiotos, A., Munteanu, D. Characterization and Antimicrobial Activity of Silver Nanoparticles, Biosynthesis Using Bacillus Species, Applied Surface Science, 438, 66-73, 2018

116.       Lifshiz-Zimon, R., Lerman, G., Elharrar, E., Meningher,T., Barzilai, A., Masalha, M., Chintaculcunta, R., Holander,E., Goldbart,R., Traitel, T., Haras, M., Sidi, Y., Avni, D., and Kost, J. Ultrasound Targeting of Q-starch/miR-197 Complexes for Topical Treatment of Psoriasis (submitted)

117.       Khoury, L., Kost, J., and  Enden, G., Effects of Surface Coating on Nanoparticle -Protein Adsorption Selectivity,  Regenerative Engineering and Translational Medicine (in press, on line March 27, 2018)


Patents

1.    Kost, J. and Langer, R. "Ultrasonically Modulated Polymeric Devices for Delivering Compositions", U.S. Patent 4,657,543.

2.    Langer, R. and Kost, J. "Ultrasonically Modulated Polymeric Devices for Delivering Compositions", U.S. Patent 4,779,806.

3.    Langer, R. and Kost, J. "Ultrasonically Modulated Polymeric Devices for Delivering Drug Compositions", Canadian Patent 1291064.

4.    Kost, J., Levy, D. and Langer, R. "Ultrasound Enhancement of Transdermal Drug Delivery", U.S. Patent 4,767,402.

5.    Kost, J. and Langer, R. "Ultrasound Enhancement of Membrane Permeability", U.S. Patent 4,780,212.

6.    Kost, J and Langer, R. "Ultrasound Enhancement of Transbuccal Drug Delivery", U.S. Patent 4,948,587.

7.    Zohar, Y., D'Amanuele, A., Kost, J. and Langer, R. "Ultrasound-Mediated Administration of Compounds into Aquatic Animals", U.S. Patent 5,076,208.

8.    Eppstein, J., Eppstein, D., Kost, J. and Langer, R. "Enhancement of Transdermal Monitoring Applications with Ultrasound and Chemical Enhancers", U.S. Patent 5,458,140.

9.    Zohar, Y., D'Amanuele, A., Kost, J. and Langer, R. "Ultrasound-Mediated Administration of Compounds into Aquatic Animals", Australian Patent 645620

10.  Langer, R. and Kost, J. "Ultrasonically Modulated Polymeric Devices for Delivering Compositions", Canadian Patent 1,291,064.

11.  Kost, J., Levy, D. and Langer, R. "Ultrasound Enhancement of Transdermal Drug Delivery", Canadian Patent 1,324,051.

12.  Kost, J., Levy, D. and Langer, R. "Ultrasound Enhancement of Transdermal Drug Delivery", European Patent 0275284.

13.  Zohar, Y., D'Amanuele, A., Kost, J. and Langer, R. "Ultrasound-Mediated Administration of Compounds into Aquatic Animals", European Patent 0548236: BE, DE-69110289T2, DK, FR, GB, GR, IT, SP.

14.  Kost, J. and Langer, R. "Ultrasonically Modulated Polymeric Devices for Delivering Compositions", European Patent 0245535: Germany DE 3685958.3.

15.  Kost, J. and Langer, R. "Ultrasonically Modulated Polymeric Devices for Delivering Compositions", European Patent 86106725.4

16.  Langer, R. and Kost, J. "Ultrasonically Modulated Polymeric Devices for Delivering Drug      Compositions", Japanese Patent 2018881.

17.  Zohar, Y., D'Amanuele, A., Kost, J. and Langer, R. "Ultrasound-Mediated Administration of Compounds into Aquatic Animals", Canadian Patent, pending.

18.  Johnson, M., Mitragotri, S., Blankschtein, D., Langer, R., Pishko, M. and Kost, J. "Chemical and Physical Enhancers and Ultrasound for Transdermal Drug", U.S. Patent 5,947,921. PCT (97/04832), European patent allowed.

19.  Zohar, Y., D'Amanuele, A., Kost, J. and Langer, R. "Ultrasound-Mediated Administration of Compounds into Aquatic Animals", Japanese Patent, pending.

20.  Kost, J., Shani, S., Lamprecht, S. and Segal, C. "Pharmaceutical Compositions Comprising Vitamin-D Analogs", Israel Patent US and International PCT, pending.

21.  Wallach, D., Kost, J. and Eliaz, R. "Pharmaceutical Compositions for Controlled Release of Soluble Receptors", US 6,083,534 and International PCT pending.

22.  Kost, J., Arad, S. and Kolany, R. "Polysaccharide Drug Delivery Matrix and Slow

23.  Release Pharmaceutical Preparation Containing It", Israeli patent 113359.

24.  Kost, J., Pliiquett, U., Mitragotri, S., Langer, R. and Weaver, J. "Effect of Electric Field and Ultrasound on Transdermal Drug Delivery", U.S. Patent 6,041,253

25.  Eliaz, R. and Kost, J. "Composition and Methods for Forming Biodegradable Implants In-Situ and Uses of These Implants", US 6,206,920 International PCT pending.

26.  Kost, J., Levy, D. and Langer, R. "Ultrasound Enhancement of Transdermal Drug Delivery, Japanese Patent 62-504399.

27.  Wallach, D., Kost, J. and Eliaz, R. "Pharmaceutical Compositions for Controlled Release of Soluble Receptors", Singapore Patent 43655.

28.  Geresh, S., Kost, J. and Remon, J-P. "A Biocompatible Adhesive System and a Bioadhesive Drug Delivery System with Controllable Release", International PCT pending.

29.  Mitragotri, S., Pliquett U., Johnson, M., Pishko, M., Kost, J., Langer, R., Weaver, J. and Blankschtein, D. "Enhanced Transdermal Transport using Ultrasound", PCT WO9704832, Australian patent (AU725269), Canadian patent (CA2200984), European patent (EP0781150), Japanese patent (JP10509632T).

30.  Rowe, S., Kost, J., Mitragotri, S. and Pishko, M. "Ultrasound Enhancement of Transdermal Transport", US 6,234,990, International PCT pending.

31.  Kost, J., Mitragotri, S. and Langer, R. "Sonophoretic Enhanced Transdermal Transport", U.S. Patent 6,190,315, PCT (WO9934857), Australian patent (AU740999), European patent (EP1045714), Japanese patent (JP2002500075T),  pending.

32.  Kost, J., Mitragotri, S., Pliquett, U. and Langer, R. "Effect of Electric Fields and Ultrasound on Transdermal Drug Delivery", US Divisional Patent pending (US 09/528,506).

33.  Custer, L., Elstrom, T., Kellogg, S., Kost, J. and Warner, N. "System, Method, and Device for Non Invasive Body Fluid Sampling and Analysis", International US 7,066,884 B2.

34.  Rowe, S., Kost, J., Mitragotri, S., Pishko, M. and Davis, M. "Ultrasound Enhancement of Transdermal Transport", US 6,491,657.

35.  Elstrom, T., Mitragotri, S., Kost, J., Kellogg, S., Warner, N. and Dimatteo, S. "Preparation for transmission and reception of electrical signals", US 6,887,239, International PCT pending.

36.  Mitragotri, S., Kost, J., Kellogg, S. and Warner, N. "Method and Apparatus for Producing Homogenous Cavitation to Enhance Transdermal Transport", US 6,620,123, International PCT pending.

37.  Rowe, S., Kost, J., Davis, M., Pishko, M. and Mitragotri, S. "Ultrasound Enhancement of Transdermal Transport", PCT (WO 9800194A2), US patent (US2002045850) pending.

38.  Mitragotri, S., Langer, R. and Kost, J. "Sonophoretic Enhanced Transdermal Transport", PCT (WO9934857), Australian patent (AU2109199), European patent (EP1045714), Japanese patent (JP2002500075T), all pending.

39.  Mitragotri, S., Kost, J., Kellogg, S. and Warner, N. "Method and Apparatus for Producing Homogenous Cavitation to Enhance Transdermal Transport", US patent 6,620123, PCT (WO35351A1). Canadian patent (CA2355187), Australian patent (AU2192100), Japanese patent (JP2002542841T), European patent (EP1139880).

40.  Mitragotri, S., Kost, J., Kellogg, S., Warner, N. and Elstrom, T. "Methods and Apparatus for Enhancement of Transdermal Transport", PCT (WO35357), Australian patent (AU2191900), European patent (EP1139886), Japanese patent (JP2002532130T), all pending.

41.  Kellogg, S., Elstrom, T., Kost, J., Mitragotri, S., Warner, N. and Dimatteo, S. "Preparation for transmission and reception of electrical signals", International  PCT pending.

42.  Kellogg, S., Barman, S., Roode, L., Farnhan, H., Moran, S., Mitragotri, S., Kost, J., and Warner, N. "Agents and methods for enhancement of transdermal transport", International PCT pending.

43.  Mitragotri, S., Kost, J., Kellogg, S., Warner, N. and Custer, L. "A Method and Device for Enhanced Transdermal Drug Delivery", PCT (WO0176553), Australian patent (AU5134901) pending.

44.  Kost, J. and Eliaz, R. "Composition for Forming Biodegradable Implants", Israeli patent (118235).

45.  Barenholz, Y., Shroeder, A. and Kost,J. “Methods for Affecting Liposome Composition by Ultrasound Irradiation” International PCT pending. US patent allowed.

46.  Park, H., Kost, J., Kobler, J., Zeitels, S., Langer, R., “A Novel Ultrasound Bioreactor Can Improve Tissue Viability in Vitro”, US Patent,  pending.

47.  Kost, J., I. Patela., A. Shroeder, L. Wolloch, and M. Hallak. “System and Method for Transfetal (amnion-chorion) membranes Transport”. International PCT pending.

48.  Pokras, M., Goldbart, R., Azoulay, M., Polak, J., Kost J. “Probe for Tagging Valuables Based on DNA-Metal Complex” International PCT pending.

49.  Chuang, H., Hurley, J., Kost, J. “ Transdermal Analyte Monitoring Systems and Methods for Analyte Detection” PCT/US2008056032

50.  Kost,J.,  Shmilowitz, D., Goldbart, R., Traitel, T., Wolloch,L., Azaguri,    A.System and Method for transfetal (Amnion Chorion) Membrane Transport Enhancement PCT pending

51.  Mitragotri, S., Kost, J., Kellogg, S., Warner, N. and Elstrom, T. "Methods and Apparatus for Enhancement of Transdermal Transport", US 8,287,483

52.  Kost,J.,  Patla, I., Shroeder, A., Wolloch, L.,Hallak, “A.System and Method for transfetal (Amnion Chorion) Membrane Transport”  Israeli Patent No 195740

53.  Kost,J.,  Patla, I., Shroeder, A., Wolloch, L.,Hallak, “A.System and Method for transfetal (Amnion Chorion) Membrane Transport”  US 8,343,134

54.  Kost,J., Halak,M., Smilovitch,D., Traitel,T.,Goldbart,R., Azaguri,A., Wolloch,L. “Pharmaceutical Composition and System for Permeabilizing Fetal Membrane. US2011/0319790 A1 pending

55.  Kost, J., Goldbart, R., Traitel, T., Lewis Amar, E., Lifshitz, R., Peer, D. “Positively Charged Polysaccharides for RNA Transfection” US 9,566,346 B2,  PCT/IL2014/050126 pending

56.  Kost, J., Azaguri, A., “Low Intensity Ultrasound Therapy” US Patent pending

57.  Laster, B., Kost, J. “The Continuous Long-Term Controlled Release of Telomerase Inhibitor” PCT/IL2014/ 050840, WO 2015/040622 pending

58.  Kost, J., Traitel, T., Goldbart, R., Attias, S., Enden, G., Kingma P., Whitsett, J.  A Controlled Release System for Pulmonary Delivery of Surfactant Protein, International PCT/IL2016/050606 pending.

59.  Kost, J., Goldbart, R., Traitel, T., Matelly, N., Rudich, A., Hollander, E. Cationic Polysaccharides for Delivery of Phosphoinositides to Cells for Therapeutic Purpose, US 15/241/293 pending.

60.  Khoury,L.,Goldbart ,R., Traitel, T., Enden, G., Kost, J. Gold Nanostructures and Uses Thereof,  US 15/203,897 pending

61.  Kost, J., Traitel, T., Goldbart, R., Buaron, N. Modified Polysaccharides For Use As Anti-Microbial Agents, PCT/IL2015/051170 pending

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